Recent advances in drug delivery systems for glaucoma treatment
نویسندگان
چکیده
Glaucoma is a chronic eye disease and the second most leading cause of irreversible impaired vision in world, which primarily linked with high intraocular pressure (IOP). The treatment glaucoma currently challenging because innate mechanics ocular barriers that limit penetration ophthalmic drugs. To tackle this, various carriers (inorganic-, polymeric-, hydrogel-, or contact lens–based) specialized physical chemical properties have been intensively studied. These carrier-drug formulations shown significant improvement aspects, such as penetration, bioavailability, sustained release drug, tissue targeting, lowering IOP. delivery systems can be administered through routes (intravitreal periocular injection systemic route), enabling drugs to reach damaged sites help recover optical nerves, thus considered an effective strategy for glaucoma. In this review, we thoroughly investigate recent advances focusing on glaucoma, including nanocarrier types, route, efficacy vitro vivo, clinical availability, future outlook.
منابع مشابه
Recent Advances in Ocular Drug Delivery Systems
Transport of drugs applied by traditional dosage forms is restricted to the eye, and therapeutic drug concentrations in the target tissues are not maintained for a long duration since the eyes are protected by a unique anatomy and physiology. For the treatment of the anterior segment of the eye, various droppable products to prolong the retention time on the ocular surface have been introduced ...
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ژورنال
عنوان ژورنال: Materials Today Nano
سال: 2022
ISSN: ['2588-8420']
DOI: https://doi.org/10.1016/j.mtnano.2022.100178